Nucleosides and Analogues
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.88% | 465.18 | 50 MG
Guanosine 5'-diphosphate (GDP) sodium is a nucleoside diphosphate that activates the adenosine 5'-triphosphate-sensitive K+ channel. It acts as an iron mobilizer by forming a complex with hepcidin, inhibiting the hepcidin-ferroportin (FPN) interaction, and modulating the IL-6/stat-3 pathway. It has been shown to ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4 and can be used in AI research.
- Activates adenosine 5'-triphosphate-sensitive K+ channel
- Acts as an iron mobilizer by forming a complex with hepcidin
- Inhibits hepcidin-ferroportin (FPN) interaction
- Modulates the IL-6/stat-3 pathway
- Ameliorates turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4
- Suitable for AI research
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 100mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC Adenosine 5'-diphosphate | 58-64-0 | 99.5% | 427.20 | 25MG
Adenosine 5'-diphosphate | 58-64-0 | 99.5% | 427.20 | 25MG
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Aminohippurate (sodium) | 94-16-6 | 99.9% | C9H9N2NaO3 | 1 ML
Aminohippurate sodium is a diagnostic agent primarily used in medical tests for measuring renal plasma flow. This product is intended for laboratory research and is not validated for medical applications.
- Used for renal plasma flow measurement
- For research use only
- Purity of 99.9%
- Supplied as a 10 mM, 1 mL solution in DMSO
- Stable under recommended storage conditions
Medchemexpress LLC 2'-Deoxyguanosine (standard) | 961-07-9 | MFCD00080300 | 99.2% | 267.24 | 50 MG
2'-Deoxyguanosine (Standard) is the analytical standard for 2'-Deoxyguanosine. It is intended for research and analytical applications. This purine nucleoside exhibits diverse biological activities, including inducing DNA division in mouse thymus cells and acting as a potent cell division inhibitor in plant cells. In vitro, it inhibits the clonal growth of HL-60 and K562 leukemia cells with IC50 values of 50 and 80 μM, respectively.
- Analytical standard for 2'-deoxyguanosine
- Intended for research and analytical applications
- Induces DNA division in mouse thymus cells
- Potent cell division inhibitor in plant cells
- Inhibits clonal growth of HL-60 and K562 leukemia cells
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Rp-cAMPS sodium salt | 142439-94-9 | 99.7% | 367.25 | C10H11N5NaO5PS | 1 MG
Rp-cAMPS sodium salt is a cyclic AMP (cAMP) analog that functions as a potent, competitive antagonist of cAMP-dependent protein kinase A (PKA) I and II. Supplied as the sodium salt for research use, it is a white-to-pink solid with high purity and is used to inhibit cAMP-mediated PKA activation in biochemical and cell signaling studies.
- Potent, competitive antagonist of cAMP-dependent PKA I and II.
- High purity (99.7%) suitable for research applications.
- Available in small solid quantities for precise dosing.
- Stable under recommended storage when sealed and protected from moisture and light.
- Compatible with biochemical and cell signaling assays to study cAMP pathways.
Selleck Chemical LLC 2 3 -Dideoxyadenosine
2 3 -Dideoxyadenosine (ddA ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication
Apexbio Technology LLC ATP Solution (100 mM) 250uL
ATP (Adenosine-5 -triphosphate) known as in Chinese is a fundamental component for energy transfer in biological systems ATP and its sodium salts can be utilized in numerous molecular biology applications such as kinase reactions in vitro transcription ligation reactions and phosphorylation assays This product is a colorless transparent aqueous solution prepared from ATP trisodium salt with a purity 99% (by HPLC) concentration of 100 mM pH (25 ) 7 0 0 1 and free of DNase RNase and phosphatase contamination